Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of intraocular pressure after subconjunctival injection of mitomycin in human glaucoma

S A Gandolfi1, M Vecchi, L Braccio

  • 1Ambulatorio Glaucoma, Istituto di Oftalmologia, Universita' di Parma, Italy.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|May 1, 1995
PubMed
Summary

Subconjunctival mitomycin injections effectively lowered intraocular pressure in human glaucoma patients. This treatment demonstrated sustained IOP reduction over 60 days, offering a potential new therapeutic avenue for managing glaucoma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Properties of Heavy Cosmic Nuclei Phosphorus, Chlorine, Argon, Potassium, and Calcium: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2026
Same author

Real-life effectiveness and safety of tofacitinib and vedolizumab as 2nd-line for ulcerative colitis after anti-TNFs: A multicenter cohort IGIBD study (VE2TO-UC).

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2025
Same author

Antiprotons and Elementary Particles over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2025
Same author

Solar Modulation of Cosmic Nuclei over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2025
Same author

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S.

Physical review letters·2024
Same author

AIEC-dependent pathogenic Th17 cell transdifferentiation in Crohn's disease is suppressed by <i>rfaP</i> and <i>ybaT</i> deletion.

Gut microbes·2024

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma progression.
  • Current treatments aim to reduce IOP but may have limitations or side effects.

Purpose of the Study:

  • To evaluate the efficacy of subconjunctival mitomycin injections in reducing intraocular pressure in patients with glaucoma.
  • To assess the duration of the IOP-lowering effect of mitomycin.

Main Methods:

  • A prospective, consecutive case series study was conducted.
  • Twelve patients with bilateral glaucoma and elevated IOP in one eye received a subconjunctival injection of mitomycin.
  • Intraocular pressure was measured before and at various time points after the intervention, with fellow eyes serving as controls.

Related Experiment Videos

Main Results:

  • A significant decrease in intraocular pressure was observed in the treated eyes the day after mitomycin injection (mean decrease of 7.15 mm Hg).
  • The IOP-lowering effect persisted for 60 days, with a mean decrease of 5.67 mm Hg.
  • No significant change in IOP was noted in the untreated fellow eyes.

Conclusions:

  • Subconjunctival mitomycin administration is effective in reducing intraocular pressure in human glaucomatous eyes.
  • The findings support a direct effect of mitomycin on aqueous humor dynamics, warranting further investigation.
  • Mitomycin may represent a valuable therapeutic option for managing elevated IOP in glaucoma.