Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The interphotoreceptor matrix mediates primate retinal adhesion

G S Hageman1, M F Marmor, X Y Yao

  • 1Department of Ophthalmology, the Anheuser-Busch Eye Institute, University School of Medicine, St Louis MO, USA.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Psoroptes ovis MIF to improve skin barrier function: A novel prophylactic strategy for psoroptic mange.

Veterinary parasitology·2026
Same author

Recombinant PsoSP4 confers superior 80% protection against psoroptic mange in rabbits in association with a Th1-biased immune response.

Veterinary parasitology·2026
Same author

Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice.

Probiotics and antimicrobial proteins·2025
Same author

Application two-dimensional gel electrophoresis coupled with LC-MS/MS to identify candidate serodiagnostic antigens for early detection Psoroptes ovis var. cuniculi infection.

Veterinary parasitology·2024
Same author

Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression.

Nature communications·2024
Same author

[Analysis of differences in health awareness among urban and rural elderly population under the background of aging].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2023

Cone matrix sheaths, part of the interphotoreceptor matrix, strongly anchor the neural retina to the retinal pigment epithelium (RPE). These sheaths act as a molecular bridge, crucial for maintaining retinal adhesion.

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biochemistry

Background:

  • The interphotoreceptor matrix (IPM) is a complex extracellular matrix surrounding photoreceptors.
  • Cone matrix sheaths (CMS) are specialized IPM domains extending from cone photoreceptors to the retinal pigment epithelium (RPE).
  • The precise role of CMS in retinal adhesion remains incompletely understood.

Purpose of the Study:

  • To investigate the role of cone matrix sheaths in mediating retinal adhesion.
  • To assess the structural integrity and attachment properties of CMS during retinal separation.

Main Methods:

  • Partial peeling of monkey and human retinas from the RPE.
  • Lectin histochemistry was employed to examine the effects of physical separation on CMS.

Related Experiment Videos

Main Results:

  • Cone matrix sheaths demonstrated strong attachment to both the RPE and neural retina.
  • Retinal peeling caused RPE detachment from Bruch's membrane or tearing of the CMS.
  • CMS exhibited significant stretching and contraction capabilities post-tearing.
  • CMS integrity degraded rapidly within the first minute postmortem.

Conclusions:

  • Cone matrix sheath glycoconjugates are key components in retinal adhesion.
  • CMS likely form a molecular bridge, connecting the neural retina and RPE.
  • These findings highlight the critical function of CMS in maintaining retinal structural integrity.