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The effects of 5-HT3 receptor antagonists in models of dependency and withdrawal
B Costall1, A M Domeney, M E Kelly
1School of Pharmacy, University of Bradford, West Yorkshire, U.K.
Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement
|January 1, 1993
Abstract:
Pharmacological manipulations to enhance 5-HT synthesis and release have been reported to reduce alcohol intake. However, recent evidence indicates that 5-HT3 receptor antagonists may also exert a similar effect in a number of species. This report reviews the existing data which implicates a central role for 5-HT3 receptors in the control of psychoactive substance abuse.