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Zinc and endothelial function

C McClain1, P Morris, B Hennig

  • 1Department of Medicine, University of Kentucky, Lexington, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|January 1, 1995
PubMed
Summary
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Zinc (Zn) is vital for cell membranes and antioxidant functions. Zinc deficiency impairs endothelial cells, but supplementation can restore barrier function, impacting vascular diseases like atherosclerosis.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Vascular Biology

Background:

  • Zinc (Zn) is an essential trace element with antioxidant properties and a role in metalloenzymes.
  • Zn deficiency affects erythrocyte membrane integrity and fluidity.
  • Endothelial barrier cell function is disrupted by Zn deficiency.

Purpose of the Study:

  • To investigate the role of zinc in endothelial barrier cell function.
  • To determine if zinc supplementation can correct Zn deficiency-induced endothelial dysfunction.
  • To explore zinc's potential in mitigating vascular inflammatory processes.

Main Methods:

  • In vitro studies examining endothelial barrier cell function.
  • Induction of Zn deficiency through various mechanisms.

Related Experiment Videos

  • Assessment of Zn supplementation effects on endothelial barrier integrity.
  • Evaluation of zinc's impact on tumor necrosis factor-induced barrier dysfunction.

    • Main Results:

    • Zn deficiency disrupts endothelial barrier cell function in vitro.
    • Zn supplementation effectively corrected the disrupted endothelial barrier function.
    • Physiological zinc amounts attenuated barrier dysfunction caused by tumor necrosis factor.
    • Zn deficiency alters erythrocyte membrane properties.

    Conclusions:

    • Zinc plays a crucial role in maintaining endothelial barrier function.
    • Zinc supplementation is a potential therapeutic strategy for vascular dysfunction.
    • These findings have implications for acute and chronic vascular diseases, including ARDS and atherosclerosis.