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Related Experiment Videos

Viruses and apoptosis

Y Shen1, T E Shenk

  • 1Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.

Current Opinion in Genetics & Development
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

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Viruses manipulate apoptosis, a controlled cell death process, to aid their replication or cause disease. Understanding these viral gene products is key to controlling viral infections.

Area of Science:

  • Cellular biology
  • Virology
  • Molecular biology

Background:

  • Apoptosis is a regulated, essential process for multicellular organisms.
  • Viruses possess gene products that can influence apoptosis.

Purpose of the Study:

  • To explore the role of viral gene products in modulating apoptosis.
  • To understand how viruses utilize apoptosis for their life cycle.

Main Methods:

  • Analysis of viral genomes for apoptosis-modulating genes.
  • Experimental investigation of viral effects on host cell apoptosis.

Main Results:

  • Viral gene products can induce or inhibit apoptosis.
  • Apoptosis induction by viruses contributes to cytopathogenic effects.

Related Experiment Videos

  • Apoptosis inhibition by viruses facilitates viral replication and spread.

    • Conclusions:

    • Viral manipulation of apoptosis is a critical factor in viral pathogenesis.
    • Targeting viral modulation of apoptosis may offer therapeutic strategies.