Cell cycle control of morphogenesis in budding yeast

A detailed description of the cytoskeletal rearrangements that orchestrate bud formation is beginning to emerge from studies on yeast morphogenesis. In this review, we focus on recent advances in our understanding of how the timing of these rearrangements is controlled. Dramatic changes in cell polarity that occur in G1 (polarization to the bud site), G2 (depolarization within the bud), and mitosis (repolarization to the mother/bud neck) are triggered by changes in the kinase activity of Cdc28, the universal regulator of cell cycle progression. The hunt for Cdc28 morphogenesis substrates is on.