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Cell cycle control of morphogenesis in budding yeast

D J Lew1, S I Reed

  • 1Duke University Medical Center, Durham, North Carolina 27710, USA.

Current Opinion in Genetics & Development
|February 1, 1995
PubMed
Summary

Yeast cell polarization during budding is orchestrated by cytoskeletal changes. Cell cycle regulator Cdc28 kinase activity controls the timing of these crucial rearrangements for morphogenesis.

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Area of Science:

  • Cell Biology
  • Microbiology
  • Biochemistry

Background:

  • Yeast morphogenesis involves complex cytoskeletal rearrangements during bud formation.
  • Understanding the precise timing of these events is crucial for cell cycle control.

Purpose of the Study:

  • To review recent advances in controlling the timing of cytoskeletal rearrangements in yeast morphogenesis.
  • To highlight the role of cell cycle progression in regulating cell polarity dynamics.

Main Methods:

  • Review of existing literature on yeast cell cycle regulation and morphogenesis.
  • Analysis of studies focusing on cytoskeletal dynamics and cell polarity.
  • Examination of the role of Cdc28 kinase activity in cell cycle progression.

Main Results:

  • Cell polarity undergoes dramatic changes during specific cell cycle phases: G1, G2, and mitosis.
  • These polarity shifts are triggered by alterations in the kinase activity of Cdc28.
  • Cdc28 is identified as a universal regulator of cell cycle progression and morphogenesis timing.

Conclusions:

  • The kinase activity of Cdc28 is a key determinant in timing yeast cytoskeletal rearrangements.
  • Further research is needed to identify specific Cdc28 morphogenesis substrates.
  • Understanding these mechanisms provides insights into cell cycle control and developmental processes.

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