Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ras signaling and NF1

F McCormick1

  • 1Onyx Pharmaceuticals, Richmond, California 94806, USA.

Current Opinion in Genetics & Development
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Neurofibromatosis type 1 (NF1) gene mutations disrupt Ras protein regulation, causing disease symptoms. However, NF1 protein may have undiscovered functions beyond Ras regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Workload for infection prevention and control teams in preventing nosocomial tuberculosis: an underestimated burden.

The Journal of hospital infection·2022
Same author

Ancient DNA, lipid biomarkers and palaeoecological evidence reveals construction and life on early medieval lake settlements.

Scientific reports·2021
Same author

Family-focused practice within a recovery framework: practitioners' qualitative perspectives.

BMC health services research·2017
Same author

In-hospital mortality risk of intertrochanteric hip fractures: a comprehensive review of the US Medicare database from 2005 to 2010.

Musculoskeletal surgery·2017
Same author

ABO-Incompatible Kidney Transplants: Twice as Expensive, Half as Good.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

A Cost-Benefit Analysis of Government Compensation of Kidney Donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
Same journal

Active processes shape and move the genome and nucleoplasm.

Current opinion in genetics & development·2026
See all related articles

Area of Science:

  • Genetics
  • Molecular Biology
  • Cellular Signaling

Background:

  • Neurofibromatosis type 1 (NF1) is an inherited disorder.
  • The NF1 gene product is a known regulator of Ras protein activity.
  • Ras pathway dysregulation is implicated in NF1 pathogenesis.

Purpose of the Study:

  • To explore the known regulatory role of the NF1 gene in Ras protein activity.
  • To investigate potential novel functions of the NF1 protein beyond Ras regulation.

Main Methods:

  • Literature review of NF1 gene function.
  • Analysis of existing data on Ras protein signaling in NF1.
  • Hypothesis generation for undiscovered NF1 protein functions.

Main Results:

Related Experiment Videos

  • The NF1 gene's role in regulating Ras activity is well-established.
  • NF1 mutations lead to Ras misregulation, contributing to disease phenotypes.
  • Evidence suggests NF1 protein possesses functions independent of Ras regulation.

Conclusions:

  • NF1 mutations primarily impact Ras signaling, explaining some disease aspects.
  • Further research is needed to elucidate the full spectrum of NF1 protein functions.
  • Understanding these additional functions may reveal new therapeutic targets for NF1.