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Biochemical properties and biological effects of p53
1Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Current Opinion in Genetics & Development
|February 1, 1995
Abstract:
Over the past year, insights have been made into the biochemistry and biological effects of p53. The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the protein, important p53 target genes (such as WAF1) have been identified, and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.