Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematologic disorders and ischemic stroke

B B Weksler1

  • 1Department of Medicine, Cornell University Medical College, New York, USA.

Current Opinion in Neurology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.

British journal of pharmacology·2015
Same author

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function.

Biomedical microdevices·2012
Same author

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2009
Same author

Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease.

Alimentary pharmacology & therapeutics·2007
Same author

Blood-brain barrier-specific properties of a human adult brain endothelial cell line.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2005
Same author

Rituximab for autoimmune haemophilia: a proposed treatment algorithm.

Haemophilia : the official journal of the World Federation of Hemophilia·2005
Same journal

Movement disorders and Parkinson's disease: collaborative and interdisciplinary research to advance understanding of neural circuit dysfunction, pathophysiology, and care: new horizons in technology, neuroimaging, neurophysiology, and genetics toward personalized medicine.

Current opinion in neurology·2026
Same journal

Editorial introduction.

Current opinion in neurology·2026
Same journal

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same journal

Tourette syndrome: brain neurophysiology, circuit dysfunction, and neuromodulation across invasive and noninvasive approaches.

Current opinion in neurology·2026
Same journal

Dystonia: from phenotypes to genetics and therapeutic advances.

Current opinion in neurology·2026
Same journal

What can we learn from eye movements in movement disorders and Parkinson's disease?

Current opinion in neurology·2026
See all related articles

Hematologic disorders increase ischemic stroke risk by promoting blood clots. Identifying these disorders helps tailor treatments, but balancing clot prevention with bleeding risk remains challenging.

Area of Science:

  • Hematology
  • Neurology
  • Vascular Medicine

Background:

  • Hematologic disorders can cause thrombotic tendencies, contributing to ischemic stroke.
  • These conditions may lead to cerebral ischemia even without other identified risk factors.
  • Specific disorders include platelet dysfunction, coagulopathies, and antiphospholipid antibody syndromes.

Purpose of the Study:

  • To explore the link between hematologic abnormalities and ischemic stroke.
  • To discuss the mechanisms underlying hematologic disorders and cerebral ischemia.
  • To highlight advancements in therapeutic approaches for stroke prevention.

Main Methods:

  • Review of hematologic disorders associated with thrombotic tendencies.
  • Analysis of mechanisms linking hematologic abnormalities to ischemic pathology.

Related Experiment Videos

  • Evaluation of novel markers for platelet, coagulation, and fibrinolysis activation.

    • Main Results:

    • Hematologic disorders represent a significant risk factor for ischemic stroke.
    • Multiple underlying mechanisms can contribute to ischemia in specific hematologic conditions.
    • Improved diagnostic markers aid in correlating prothrombotic mechanisms with ischemic events.

    Conclusions:

    • Hematologic disorders are crucial considerations in the etiology of ischemic stroke.
    • Precise therapeutic strategies are emerging with better understanding of prothrombotic mechanisms.
    • Balancing the prevention of cerebral ischemia against the risk of hemorrhagic toxicity is an ongoing clinical challenge.