Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunology of multiple sclerosis

K C Williams1, E Ulvestad, W F Hickey

  • 1Department of Pathology, Dartmouth Medical School-DHMC, Lebanon, NH 03756, USA.

Clinical Neuroscience (New York, N.Y.)
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Ecosystem Approach in the 21<sup>st</sup> Century: Guiding Science and Management - A Synthesis.

Aquatic ecosystem health & management·2026
Same author

Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield.

Scientific reports·2022
Same author

The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same author

Increased infiltration and tolerised antigen-specific CD8<sup>+</sup> T<sub>EM</sub> cells in tumor but not peripheral blood have no impact on survival of HCMV<sup>+</sup> glioblastoma patients.

Oncoimmunology·2017
Same author

Investigation of falsified documents via direct analyte-probed nanoextraction coupled to nanospray mass spectrometry, fluorescence microscopy, and Raman spectroscopy.

The Analyst·2015
Same author

Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission.

Neuropharmacology·2015

Multiple sclerosis (MS) involves immune cells like T cells, B cells, macrophages, and microglia in CNS inflammation and demyelination. Research highlights their interactions and roles in MS pathogenesis, supported by experimental allergic encephalomyelitis (EAE) models.

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Central Nervous System (CNS) Pathology

Background:

  • Multiple sclerosis (MS) is a CNS autoimmune disorder characterized by inflammation, demyelination, and oligoclonal IgG production.
  • Key immune cells implicated include T cells, B cells, macrophages, and microglia.

Purpose of the Study:

  • To review the roles of T cells, B cells, macrophages, and microglia in MS initiation and perpetuation.
  • To discuss interactions between these cells, serum/CSF proteins, and the blood-brain barrier (BBB).
  • To examine antigen presentation within the CNS and T cell involvement in inflammatory events.

Main Methods:

  • Review of existing clinical and experimental data.
  • Analysis of findings from the experimental allergic encephalomyelitis (EAE) rodent model.

Related Experiment Videos

  • Discussion of cellular and molecular interactions in MS pathogenesis.

    • Main Results:

    • Evidence supports the involvement of T cells, B cells, macrophages, and microglia in MS pathology.
    • Cellular interactions with the BBB, CNS immune cell trafficking, and antigen presentation are crucial.
    • T cells play a significant role in initiating, amplifying, and potentially terminating CNS inflammation.

    Conclusions:

    • Immune cell dynamics and interactions are central to MS pathogenesis.
    • Understanding these mechanisms offers insights into potential therapeutic targets for MS.
    • T cell activation and cytokine production patterns are critical in CNS inflammatory responses.