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[Penicillin resistance of pneumococci from invasive pediatric infections]
A Goldbart1, P Yagupsky, R Dagan
1Pediatric Infectious Disease Unit, Soroka Medical Center, Beer Sheba.
Insights
Antibiotic resistance in Streptococcus pneumoniae is increasing, with 18% of isolates resistant to penicillin. This rise in penicillin resistance correlates with resistance to other antibiotics, impacting treatment strategies.
Area of Science:
- Microbiology
- Infectious Diseases
- Pediatrics
Abstract:
Susceptibility to antibiotics of 199 isolates of Streptococcus pneumoniae from blood and cerebrospinal fluid of children hospitalized during 1987-1993 was tested. Of 119 isolates, 18% were resistant to penicillin. The prevalence in 1992-93 was double that in 1987-89. The increase in minimal inhibitory concentrations (MIC) of penicillin was associated with an increase in MIC of other beta-lactams. There was also resistance to other antibiotics: trimethoprim-sulfamethoxazole, erythromycin and chloramphenicol. Most of the resistant isolates belonged to serogroups 6, 14, 19 and 23. When planning vaccine policies, resistant types should be taken into consideration.