Related Experiment Videos
"Quilty" revisited: a 10-year perspective
A Joshi1, M A Masek, B W Brown
1Department of Pathology, Stanford University School of Medicine, CA 94305-5247, USA.
Human Pathology
|May 1, 1995
Summary
Quilty lesions in heart transplants are common and do not appear to be associated with rejection or infection. However, Quilty-positive patients showed a significant decrease in graft vascular disease.
Area of Science:
- Cardiology
- Transplant Immunology
- Pathology
Background:
- Quilty lesions are common findings in endomyocardial biopsies after heart transplantation.
- Differentiating Quilty lesions from other infiltrates and understanding their clinical significance is crucial for patient management.
Purpose of the Study:
- To define Quilty lesions and differentiate them from other endocardial infiltrates.
- To correlate Quilty lesions with clinical parameters and assess the utility of classifying them as Quilty A (noninvasive) or Quilty B (invasive).
Main Methods:
- Review of clinical, angiographic, and biopsy data from 217 adult and 22 pediatric heart transplant recipients.
- Classification of Quilty lesions and assessment of International Society for Heart and Lung Transplantation (ISHLT) rejection grades.
- Immunohistochemistry to determine Quilty cell composition.
Main Results:
- Quilty lesion incidence was 49.77% in adults and 68.18% in children.
- No association found between Quilty lesions and recipient age, gender, cytomegalovirus (CMV), Epstein-Barr virus (EBV) infection, or lymphoma.
- Quilty-positive patients demonstrated a significant decrease in graft vascular disease (GVD).
Conclusions:
- The distinction between Quilty A and B lesions lacks clinical significance.
- Quilty lesions are frequent post-transplant findings, generally not associated with acute rejection.
- Further research is needed to clarify findings in pediatric heart transplant recipients due to small sample size.