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Related Experiment Videos

"Quilty" revisited: a 10-year perspective

A Joshi1, M A Masek, B W Brown

  • 1Department of Pathology, Stanford University School of Medicine, CA 94305-5247, USA.

Human Pathology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

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Quilty lesions in heart transplants are common and do not appear to be associated with rejection or infection. However, Quilty-positive patients showed a significant decrease in graft vascular disease.

Area of Science:

  • Cardiology
  • Transplant Immunology
  • Pathology

Background:

  • Quilty lesions are common findings in endomyocardial biopsies after heart transplantation.
  • Differentiating Quilty lesions from other infiltrates and understanding their clinical significance is crucial for patient management.

Purpose of the Study:

  • To define Quilty lesions and differentiate them from other endocardial infiltrates.
  • To correlate Quilty lesions with clinical parameters and assess the utility of classifying them as Quilty A (noninvasive) or Quilty B (invasive).

Main Methods:

  • Review of clinical, angiographic, and biopsy data from 217 adult and 22 pediatric heart transplant recipients.
  • Classification of Quilty lesions and assessment of International Society for Heart and Lung Transplantation (ISHLT) rejection grades.

Related Experiment Videos

  • Immunohistochemistry to determine Quilty cell composition.

    • Main Results:

    • Quilty lesion incidence was 49.77% in adults and 68.18% in children.
    • No association found between Quilty lesions and recipient age, gender, cytomegalovirus (CMV), Epstein-Barr virus (EBV) infection, or lymphoma.
    • Quilty-positive patients demonstrated a significant decrease in graft vascular disease (GVD).

    Conclusions:

    • The distinction between Quilty A and B lesions lacks clinical significance.
    • Quilty lesions are frequent post-transplant findings, generally not associated with acute rejection.
    • Further research is needed to clarify findings in pediatric heart transplant recipients due to small sample size.