Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Acrodermatitis chronica atrophicans: a light and electron microscopic study

J de Koning¹, D J Tazelaar, J A Hoogkamp-Korstanje

¹Department of Pathology, Public Health Laboratory, Leeuwarden, The Netherlands.

Journal of Cutaneous Pathology

|February 1, 1995

Summary

Acrodermatitis chronica atrophicans involves degeneration of skin elastic and collagen fibers. This study reveals spirochetes in most biopsies, potentially causing skin elasticity loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Risk factors for lower extremity injuries among half marathon and marathon runners of the Lage Landen Marathon Eindhoven 2012: A prospective cohort study in the Netherlands.

Scandinavian journal of medicine & science in sports·2015

Same author

Relationship between plantar pressure distribution under the foot and insole comfort.

Clinical biomechanics (Bristol, Avon)·2013

Same author

Authors' reply to périard: "cardiovascular determinants involved in pacing under heat stress" : the complex skill of pacing: is there an interplay between central and peripheral determinants?

Sports medicine (Auckland, N.Z.)·2013

Same author

Purification of a candidate gonadotrophin surge-inhibiting/attenuating factor (GnSIF/AF) showing MAPK as a possible target.

Molecular reproduction and development·2011

Same author

Inadvertent infusion of potassium chloride via an epidural catheter.

Acta anaesthesiologica Belgica·2007

Same author

Development of indirect potable reuse in impacted areas of the United States.

Water science and technology : a journal of the International Association on Water Pollution Research·2007

Area of Science:

Dermatology
Microbiology
Histopathology

Background:

Acrodermatitis chronica atrophicans (ACA) is an inflammatory skin condition.
ACA leads to skin atrophy and loss of elasticity.

Purpose of the Study:

To investigate the microstructural changes in skin biopsies from ACA patients.
To identify the presence of spirochetes in ACA lesions.

Main Methods:

Light and electron microscopy of skin biopsies.
Histopathological examination for fiber degeneration and spirochetes.

Main Results:

Degeneration of elastic and collagen fibers observed, particularly in the atrophic phase.
Spirochetes detected in 69% of biopsies, prevalent in active lesions.

Related Experiment Videos

Myelin sheath collapse noted without axon structures.

Conclusions:

The loss of skin elasticity in ACA is linked to the destruction of elastic and elastin fibers.
Spirochetes are frequently present in ACA, suggesting a role in pathogenesis.