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Formation of filamentous and multivesicular bodies after intrathecal MK-801 injection
J Orendácová1, M Marsala, J Marsala
1Neurobiological Institute, Slovak Academy of Sciences.
Journal Fur Hirnforschung
|January 1, 1995
Abstract:
Our study of ultrastructural changes in lumbar spinal cord is based on the rats permanent intrathecal (IT) catheter model of MK-801 injection. After 3 days survival with the IT catheter the animals were treated by injection of MK-801 or saline. Five hrs post-treatment the rats were transcardially perfused with 4% paraformaldehyde in 0.1 M PB. L4-5 segments of the spinal cord were dissected and processed for EM. The presence of single or multiple filamentous/multivesicular bodies in neuronal cytoplasm of MK-801 treated animals was apparent.