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Association of symptoms with Helicobacter pylori infection in children
S M Gormally1, N Prakash, M T Durnin
1Department of Paediatrics, University College Dublin, Ireland.
Insights
Helicobacter pylori (H. pylori) gastritis symptoms improved after treatment in only 38% of children. In contrast, all children with H. pylori-related duodenal ulcers experienced symptom relief post-treatment.
Area of Science:
- Gastroenterology
- Pediatric Medicine
- Infectious Diseases
Background:
- Helicobacter pylori infection is a common cause of gastritis and peptic ulcer disease in children.
- The relationship between H. pylori-associated gastritis and specific symptoms, and the impact of treatment on these symptoms, requires further investigation.
Purpose of the Study:
- To prospectively assess the association between Helicobacter pylori-associated gastritis and specific symptoms.
- To evaluate whether symptom resolution occurs following successful eradication of H. pylori infection.
Main Methods:
- Prospective study evaluating children with H. pylori-associated gastritis and duodenal ulcer disease.
- Assessment of symptom presence and resolution after H. pylori eradication therapy.
Main Results:
- Symptom resolution was observed in only 3 out of 8 children (38%) with H. pylori-associated gastritis alone.
- All 6 children with H. pylori-associated duodenal ulcer disease experienced complete symptom resolution after treatment.
Conclusions:
- Helicobacter pylori eradication provides significant symptom relief for children with duodenal ulcers.
- Symptom resolution is less consistently associated with H. pylori eradication in children with gastritis alone, suggesting other factors may contribute to symptoms.
Abstract:
The aim of this study was to determine prospectively whether Helicobacter pylori-associated gastritis is associated with specific symptoms by evaluating whether these symptoms are relieved by treatment of the infection. Symptoms resolved after the eradication of H. pylori in only three of eight children with H. pylori-associated gastritis alone, in comparison with all six children with duodenal ulcer disease.