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Related Experiment Videos

Furosemide-associated fever

H W Clegg1, D A Riopel

  • 1Eastover Pediatrics, Sanger Clinic, Charlotte, North Carolina, USA.

The Journal of Pediatrics
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Fever of unknown origin in an infant was caused by furosemide. Discontinuing the medication resolved the fever, which returned upon reintroduction, confirming drug-induced fever.

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Area of Science:

  • Pediatrics
  • Clinical Pharmacology
  • Internal Medicine

Background:

  • Fever of unknown origin (FUO) presents a diagnostic challenge in infants.
  • Exhaustive evaluations are often required to identify the underlying cause of FUO.

Observation:

  • A 5-month-old infant presented with a 7-week history of FUO.
  • The infant underwent extensive investigations to determine the cause of the persistent fever.

Findings:

  • Furosemide, a loop diuretic, was identified as the causative agent for the infant's fever.
  • Discontinuation of furosemide led to the resolution of the fever.
  • Reintroduction of furosemide resulted in the recurrence of the fever, establishing a clear causal link.

Implications:

Related Experiment Videos

  • This case highlights the importance of considering medication side effects, even in young infants, when diagnosing FUO.
  • Furosemide should be recognized as a potential cause of drug-induced fever.
  • Clinicians should maintain a high index of suspicion for drug fever in infants with unexplained prolonged fever.