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Enuresis in sickle cell disease

T E Figueroa1, E Benaim, S T Griggs

  • 1Department of Surgery, University of South Florida Health Science Center, Tampa, USA.

The Journal of Urology
|June 1, 1995
PubMed
Summary
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Nocturnal enuresis (bedwetting) is common in sickle cell disease patients. Intranasal desmopressin acetate effectively treated enuresis in 60% of patients studied.

Area of Science:

  • Hematology
  • Pediatrics
  • Urology

Background:

  • Sickle cell disease (SCD) is a group of inherited red blood cell disorders.
  • Enuresis, or bedwetting, is a common condition that can affect individuals with chronic diseases.
  • The prevalence and management of enuresis in SCD patients are not well-established.

Purpose of the Study:

  • To determine the prevalence of primary nocturnal enuresis in pediatric and young adult patients with sickle cell disease.
  • To evaluate the effectiveness of intranasal desmopressin acetate as a treatment for nocturnal enuresis in this population.

Main Methods:

  • A survey was conducted among 91 active sickle cell disease patients aged 6 to 21 years.
  • Patients were assessed for symptoms of primary nocturnal enuresis.

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  • A subset of patients with enuresis received intranasal desmopressin acetate treatment.

    • Main Results:

    • 29.6% of the surveyed sickle cell disease patients (27 out of 91) reported primary nocturnal enuresis.
    • Enuresis was observed across various SCD genotypes, including sickle cell anemia and hemoglobin sickle cell disease.
    • 60% (6 out of 10) of patients treated with desmopressin acetate experienced complete or partial resolution of nocturnal enuresis.

    Conclusions:

    • Nocturnal enuresis is highly prevalent in patients with sickle cell disease.
    • Intranasal desmopressin acetate demonstrates significant efficacy in managing nocturnal enuresis in this patient group.
    • Further research is warranted to explore the underlying mechanisms and optimize treatment strategies.