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[Parathyroid crisis]

T Asagoe1, H Takami, Y Hanatani

  • 11st Department of Surgery, Teikyo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1995
PubMed
Summary
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Parathyroid crisis, a severe form of primary hyperparathyroidism, can cause life-threatening hypercalcemia. Early surgical intervention (parathyroidectomy) alongside hydration is crucial for effective treatment and symptom resolution.

Area of Science:

  • Endocrinology
  • Neurosurgery

Context:

  • Primary hyperparathyroidism can manifest as parathyroid crisis, a rare condition.
  • This crisis is defined by severe, life-threatening hypercalcemia.
  • Psychoneurotic symptoms can accompany marked hypercalcemia in primary hyperparathyroidism.

Purpose:

  • To investigate the clinical presentation and treatment outcomes of patients experiencing parathyroid crisis.
  • To evaluate the efficacy of early surgical intervention versus prolonged medical management.

Summary:

  • Nine patients with primary hyperparathyroidism and severe hypercalcemia (average 16.1 mg/dl) were treated.
  • Initial management involved hydration and medications (saline, furosemide, calcitonin) for 10-30 days.
  • Subsequent parathyroidectomy led to uneventful recovery and significant improvement in psychoneurotic symptoms.

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Impact:

  • Parathyroidectomy is an effective treatment for parathyroid crisis.
  • Prompt management of dehydration and early surgical intervention are recommended over prolonged medication.
  • No renal or cardiac dysfunction was observed postoperatively, indicating a favorable safety profile.