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Regulation of cyclic AMP-dependent Cl- channel in heart
T Ehara1, I Iyadomi, K Hirahara
1Department of Physiology, Saga Medical School, Japan.
The Japanese Journal of Physiology
|January 1, 1994
Abstract:
(1) alpha 1-Adrenoceptor stimulation inhibited the beta-adrenergic activation of Cl- current in guinea-pig ventricular cells. This alpha 1- and beta-adrenergic interaction appeared to be upstream in the cascade of adenylate cyclase activation. (2) Single Cl(-)-channel currents were recorded in cell-attached and excised outside-out patch membranes. Experiments were performed to investigate the dependence of channel behavior on the agonist concentrations.