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Published on: June 21, 2013
Activation of the basolateral Cl- conductance by cyclic AMP in rabbit renal proximal tubule S3 segment
G Seki1, S Taniguchi, S Uwatoko
1First Department of Internal Medicine, University of Tokyo, Japan.
Abstract:
The regulation of basolateral Cl- conductance in renal proximal tubule was investigated by microelectrodes. Our results suggest that this conductance can be activated by cAMP, while increase in cell Ca2+ or activation of PKC has no effect. These properties of this conductance also suggest that CFTR may exist in the basolateral membrane of proximal tubule.
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