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Region II of the Haemophilus influenzae type be capsulation locus is involved in serotype-specific polysaccharide
J Van Eldere1, L Brophy, B Loynds
1Rega Institute for Medical Research, Catholic University of Leuven, Belgium.
Molecular Microbiology
|January 1, 1995
Abstract:
The central (serotype-specific) Region II of the Haemophilus influenzae Type b capsulation locus cap is 8.3 kb long and contains a cluster of four genes. We show that these genes, designated orf1 to orf4, are involved in the biosynthetic steps required for the formation of the Type b capsular polysaccharide and that orf1 probably encodes a CDP-ribitolpyrophosphorylase. We present evidence that growth of polysaccharide chains takes place through the alternating addition of single sugar nucleotides.