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Genotoxic effects of deltamethrin in the mouse bone marrow micronucleus assay

G Gandhi1, J B Chowdhury, P K Sareen

  • 1Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.

Mutation Research
|April 1, 1995
PubMed

Insights

Deltamethrin exposure in mice induced genotoxicity, evidenced by increased micronuclei at higher doses. Lower doses of this insecticide did not show significant genotoxic effects in the bone marrow micronucleus assay.

Area of Science:

  • Toxicology
  • Genetics
  • Pesticide Research

Background:

  • Deltamethrin is a widely used synthetic pyrethroid insecticide.
  • Understanding the genotoxic potential of pesticides is crucial for risk assessment.
  • Previous studies have indicated varying toxicological profiles for deltamethrin.

Purpose of the Study:

  • To evaluate the genotoxicity of deltamethrin in a mammalian model.
  • To determine dose-dependent effects of deltamethrin on genetic material.
  • To establish a safe threshold for deltamethrin exposure in vivo.

Main Methods:

  • The bone marrow micronucleus assay was employed in Swiss albino male mice.
  • Animals received two intraperitoneal injections of deltamethrin at specified intervals.
  • Deltamethrin doses ranged from 32.5 to 300.0 mg/kg body weight.

Main Results:

  • Deltamethrin induced a significant increase in micronuclei formation at doses of 162.5 and 300.0 mg/kg.
  • A lower dose of 32.5 mg/kg deltamethrin did not result in a significant genotoxic response.
  • The assay confirmed dose-dependent genotoxic activity of deltamethrin.

Conclusions:

  • Deltamethrin exhibits genotoxic properties in mice at higher exposure levels.
  • The bone marrow micronucleus assay is a sensitive method for detecting deltamethrin-induced genotoxicity.
  • Further research may be warranted to establish comprehensive safety guidelines for deltamethrin use.

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