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Related Experiment Videos

Sequential signalling during Caenorhabditis elegans vulval induction

J S Simske1, S K Kim

  • 1Department of Developmental Biology, Stanford University Medical School, California 94305, USA.

Nature
|May 11, 1995
PubMed
Summary
This summary is machine-generated.

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Cell signaling in Caenorhabditis elegans vulva development involves sequential induction. The anchor cell signals P6.p to adopt the primary fate, which then signals P5.p and P7.p to adopt the secondary fate.

Area of Science:

  • Developmental biology
  • Cell signaling
  • Genetics

Background:

  • Vulva development in Caenorhabditis elegans involves cell fate patterning.
  • Initially equipotent cells adopt distinct fates based on position and signaling.

Purpose of the Study:

  • To investigate the signaling mechanisms underlying Caenorhabditis elegans vulva precursor cell fate determination.
  • To determine if sequential signaling events generate the stereotypical vulval cell fate pattern.

Main Methods:

  • Utilized genetic mosaic analysis in Caenorhabditis elegans.
  • Examined vulval precursor cell fates in animals with defects in anchor-cell signal transduction.

Main Results:

  • P5.p and P7.p adopted secondary cell fates even when anchor-cell signal transduction was defective.

Related Experiment Videos

  • Anchor-cell signal transduction is not essential for secondary cell fate acquisition in P5.p and P7.p.

    • Conclusions:

    • The anchor cell likely induces P6.p to adopt the primary cell fate.
    • P6.p subsequently signals P5.p and P7.p to adopt the secondary cell fate, suggesting a sequential induction model.