Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Randomized clinical trials. Perspectives on some recent ideas

D P Byar, R M Simon, W T Friedewald

    The New England Journal of Medicine
    |July 8, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice.

    Radiation research·2010
    Same author

    Work pattern causes bias in self-reported activity duration: a randomised study of mechanisms and implications for exposure assessment and epidemiology.

    Occupational and environmental medicine·2008
    Same author

    Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929).

    Statistics in medicine·2007
    Same author

    Countermeasures against space radiation induced oxidative stress in mice.

    Radiation and environmental biophysics·2007
    Same author

    The protease inhibitor, Bowman-Birk Inhibitor, suppresses experimental autoimmune encephalomyelitis: a potential oral therapy for multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2007
    Same author

    Statistical issues in interpreting clinical trials.

    Journal of internal medicine·2004
    Same journal

    Ebola at 50 - Lessons for Outbreak Response and Preparedness.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients. Reply.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    See all related articles

    Randomized clinical trials are essential for evaluating therapy efficacy, despite ongoing debates. They offer superior patient protection and reliable results compared to non-randomized or adaptive methods in complex medical research.

    Area of Science:

    • Medical Research Methodology
    • Clinical Trial Design
    • Evidence-Based Medicine

    Background:

    • The role of randomized clinical trials (RCTs) in medical research is debated.
    • Alternative non-randomized study designs, like historical controls, are proposed.
    • Statistical innovations for clinical trials, such as adaptive allocation and sequential stopping, are suggested as underutilized.

    Purpose of the Study:

    • To evaluate the continued rationale and persuasiveness of randomized clinical trials.
    • To assess the suitability of alternative non-randomized study designs.
    • To examine the applicability of advanced statistical innovations in complex medical trials.

    Main Methods:

    • Comparative analysis of randomized versus non-randomized study designs.

    Related Experiment Videos

  • Discussion of the theoretical versus practical application of statistical innovations.
  • Ethical considerations in patient protection within different trial frameworks.

    • Main Results:

    • The rationale for RCTs remains persuasive despite controversies.
    • Non-randomized studies with historical controls present challenges.
    • Advanced statistical innovations are difficult to implement in large-scale, multi-endpoint trials with delayed responses.
    • Ethical considerations favor RCTs for patient protection.

    Conclusions:

    • Randomized clinical trials are the most reliable method for evaluating therapy efficacy.
    • Ethical considerations strongly support the use of RCTs over uncontrolled experimentation.
    • The practical limitations of alternative methods and statistical innovations reinforce the value of RCTs.