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Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta
E Okuyama1, K Umeyama, M Yamazaki
1Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Planta Medica
|April 1, 1995
Abstract:
Diffractaic acid and usnic acid were identified as the analgesic and antipyretic components of a lichen, Usnea diffracta. Both compounds showed an analgesic effect by the acetic acid-induced writhing and tail-pressure methods in mice. Regarding the effect on normal body temperature and LPS-induced hyperthermia in mice, diffractaic acid showed a significant effect only on the former and usnic acid only on the latter.