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Related Experiment Videos

Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds

R A Wise1, E Munn

  • 1Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.

Psychopharmacology
|January 1, 1995
PubMed
Summary

Chronic amphetamine treatment causes a dependence syndrome. This syndrome includes a temporary decrease in the brain

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Amphetamine dependence is a significant public health concern.
  • Understanding the neurobiological underpinnings of amphetamine dependence is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the effects of chronic amphetamine treatment on intracranial self-stimulation (ICSS).
  • To characterize the withdrawal-induced changes in brain reward mechanisms following amphetamine exposure.

Main Methods:

  • Rats underwent a 6-week escalating dose amphetamine treatment regimen.
  • ICSS was measured using rate-frequency functions in the lateral hypothalamus.
  • ICSS was assessed during withdrawal and after subsequent amphetamine re-administration.

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Main Results:

  • Amphetamine withdrawal led to increased ICSS thresholds and decreased maximal response rates.
  • These deficits recovered to baseline levels within two weeks of amphetamine cessation.
  • Previously treated animals showed no significant differences in ICSS from controls when tested under amphetamine.

Conclusions:

  • Chronic amphetamine administration induces a dependence syndrome characterized by a phasic depression of reward pathway function.
  • The brain's reward mechanism shows significant, yet reversible, neuroadaptations following chronic amphetamine exposure.