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Related Experiment Videos

Control of human parturition

D M Olson1, J E Mijovic, D W Sadowsky

  • 1Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Canada.

Seminars in Perinatology
|February 1, 1995
PubMed
Summary
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Parturition involves interdependent physiological events, not a withdrawal from pregnancy. Labor initiation is triggered by stimulators like estrogen and prostaglandins, activating tissues rather than diminishing progesterone.

Area of Science:

  • Reproductive Physiology
  • Maternal-Fetal Medicine

Background:

  • Parturition is a complex, interdependent physiological process.
  • Myometrial contractility regulation is part of a continuum, not isolated.
  • Labor initiation involves biochemical events leading to cervical changes and uterine contractions.

Purpose of the Study:

  • To examine the regulation of myometrial contractility within the continuum of parturition.
  • To investigate the roles of maternal estrogen and prostaglandins in labor initiation.
  • To explore potential roles of cytokines in coordinating labor events.

Main Methods:

  • Review of existing literature on parturition physiology.
  • Analysis of biochemical events and hormonal regulation during labor.
  • Consideration of novel mediators like cytokines in labor coordination.

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Main Results:

  • Labor is suggested to be superimposed upon pregnancy, not a withdrawal.
  • Evidence does not support a decrease in progesterone at term.
  • Maternal estrogen (from fetal DHEAS) and prostaglandins are key candidates for labor initiation.

Conclusions:

  • Parturition involves activation of target tissues by stimulators, not diminished progesterone.
  • Further research is needed to clarify the synthesis and actions of prostaglandins.
  • Cytokines may play a role in coordinating labor events.