[Rat brain gangliosides under the combined effect of hypercapnia, hypoxia and hypothermia]

The paper deals with the content and composition of brain gangliosides under two forms of acute hypoxia, hypoxic and hemic ones which develop as a result of the effect of gradually increasing concentration of CO2, decreasing concentration of O2 and external cooling (1st form) and parenteral introduction of sodium nitrite (2nd form). The increase of a sum of polysialogangliosides and decrease of monosialogangliosides under the 1st and 2nd forms of acute hypoxia, respectively, is shown. The increase of the content of unsaturated fatty acids and fatty acids with the great number of carbon atoms as well as the products of lipids peroxidation is more expressed under the 2nd form of hypoxia. The decrease of antioxidative power of blood is also noticed. It is supposed that polysialogangliosides possess antiperoxide effect and preserve neuronal membranes for destruction under acute form of hypoxia.