Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anal cancer: multimodal therapy

P M Schlag1, M Hünerbein

  • 1Robert Rössle Hospital for Oncology, Department of Surgery, Free University of Berlin, Germany.

World Journal of Surgery
|March 1, 1995
PubMed
Summary

Radiochemotherapy, combining radiation and chemotherapy, is the most effective treatment for advanced anal cancer. This approach offers improved survival rates and locoregional tumor control, making it the recommended primary therapy for most patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of biofeedback pelvic floor training with ACTICORE1 on fecal incontinence A prospective multicentric cohort pilot study.

International journal of surgery (London, England)·2022
Same author

Repeated cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy in patients with peritoneal carcinomatosis: A retrospective cohort study.

Annals of medicine and surgery (2012)·2021
Same author

The negative pressure wound therapy may salvage the infected mesh following open incisional hernia repair.

Annals of medicine and surgery (2012)·2021
Same author

Ultrasound-versus visual-guided transversus abdominis plane block prior to transabdominal preperitoneal ingunial hernia repair. A retrospective cohort study.

Annals of medicine and surgery (2012)·2020
Same author

SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.

Oncogene·2015
Same author

The Influence of Intraoperative Factors and Histopathological Staging on the Performance of Sentinel Node Biopsy in Colon Cancer.

Acta chirurgica Belgica·2015

Area of Science:

  • Gastroenterology
  • Oncology

Background:

  • Anal cancer is a rare gastrointestinal malignancy, often lacking established treatment guidelines due to its infrequency.
  • Historically, radical surgery (abdominoperineal rectotomy) was primary but resulted in high recurrence rates (20-40%) and functional impairment.

Purpose of the Study:

  • To evaluate the efficacy of various treatment modalities for anal cancer.
  • To assess the role of multimodal therapy, specifically radiochemotherapy, in improving outcomes and preserving sphincter function.

Main Methods:

  • Review of treatment options including surgery, radiotherapy, and chemotherapy.
  • Focus on multimodal therapy combining radiation (50 Gy) with chemotherapy (5-fluorouracil and mitomycin C).

Main Results:

  • Radiochemotherapy demonstrates high rates of locoregional tumor control (60-80%) in advanced anal cancer.
  • Evidence suggests radiochemotherapy improves disease-free survival compared to historical treatments.
  • Despite toxicity, this approach is considered the most efficient therapy currently available.

Conclusions:

  • Radiochemotherapy is the most effective treatment for advanced anal cancer.
  • It offers superior locoregional control and improved survival, with sphincter preservation as a key benefit.
  • Recommended as the primary therapeutic strategy for most patients with advanced anal cancer.

Related Experiment Videos