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Related Experiment Videos

Head trauma and leucocytosis

S Keskil1, M K Baykaner, N Ceviker

  • 1Department of Neurosurgery, Gazi University, Faculty of Medicine, Ankara, Turkey.

Acta Neurochirurgica
|January 1, 1994
PubMed
Summary

Elevated white blood cell counts in head trauma patients indicate a poor prognosis. A count over 20 x 10(6)/l is linked to 96% mortality, highlighting its significance in predicting outcomes.

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Area of Science:

  • Neurology
  • Hematology
  • Trauma Medicine

Background:

  • Head trauma is a significant cause of mortality and morbidity.
  • White blood cell count (WBC) is a common biomarker, but its role in acute head injury prognosis needs further elucidation.

Purpose of the Study:

  • To investigate the association between white blood cell counts and clinical outcomes in patients with head trauma.
  • To determine the prognostic value of elevated WBC counts in predicting mortality following head injury.

Main Methods:

  • Prospective analysis of 153 head trauma cases.
  • Measurement and correlation of white blood cell counts with clinical grade on admission.
  • Statistical analysis to determine sensitivity and specificity for mortality prediction.

Main Results:

  • A white blood cell count exceeding 20 x 10(6)/l was significantly associated with a poor clinical grade.
  • Patients with WBC counts > 20 x 10(6)/l exhibited a 96% mortality rate.
  • WBC counts within or slightly above the normal range were associated with a 23% mortality rate.

Conclusions:

  • Elevated white blood cell count (> 20 x 10(6)/l) is a strong predictor of poor prognosis and high mortality in head trauma patients.
  • WBC count serves as a sensitive (96%) and specific (77%) biomarker for predicting mortality in this population.

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