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Related Experiment Videos

Dilantin-associated lymphadenopathy. Spectrum of histopathologic patterns

S L Abbondazo1, N S Irey, G Frizzera

  • 1Department of Hematologic and Lymphatic Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA.

The American Journal of Surgical Pathology
|June 1, 1995
PubMed
Summary

Dilantin (hydantoin) therapy can cause lymphadenopathy, including pseudolymphoma and lymphoma. This study reviewed 25 cases, finding varied histology and potential progression to malignancy.

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Area of Science:

  • Pathology
  • Toxicology
  • Oncology

Background:

  • Dilantin (hydantoin) therapy is linked to lymphadenopathy, but details are scarce.
  • Previous reports often lack comprehensive pathologic information.

Purpose of the Study:

  • To describe clinicopathologic features of Dilantin-associated lymphadenopathy.
  • To confirm the heterogeneity and nonspecificity of histologic patterns.

Main Methods:

  • Reviewed 25 lymph node lesions suspected of Dilantin association (1965-1991).
  • Assessed histologic features and immunophenotypic data.
  • Classified cases based on "operational degrees of certainty" for drug association.

Main Results:

  • 15 cases showed benign histology (immunoblastic hyperplasia), 7 were non-Hodgkin's lymphoma, 3 were Hodgkin's disease.

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  • Lymphadenopathy developed 1 week to 30 years after starting Dilantin.
  • Two cases showed progression from hyperplasia to malignant lymphoma.

    • Conclusions:

    • Dilantin-associated lymphadenopathy exhibits diverse and nonspecific histologic patterns.
    • The findings highlight the importance of considering drug-induced reactions in lymphadenopathy evaluation.
    • Further research is needed to fully understand the mechanisms and long-term implications.