Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Adipose tissue. Hidden aspects]

G Ailhaud1

  • 1Centre de Biochimie (UMR 134 CNRS), Université de Nice-Sophia Antipolis, Faculté des Sciences, Parc Valrose.

Annales D'Endocrinologie
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is obesity an adaptative response to inflammation?

Obesity reviews : an official journal of the International Association for the Study of Obesity·2012
Same author

Omega-6 fatty acids and excessive adipose tissue development.

World review of nutrition and dietetics·2008
Same author

[Development of adipose tissue and dietary lipids: from basic science to medicine].

Annales d'endocrinologie·2005
Same author

The human adipose tissue is a source of multipotent stem cells.

Biochimie·2005
Same author

Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2004
Same author

Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2003

Adipose differentiation involves sequential cell stages, with hormones and fatty acids regulating the final fat cell development. Mature fat cells secrete compounds, linking excess adipose tissue to various health issues.

Area of Science:

  • Cell Biology
  • Endocrinology
  • Metabolism

Background:

  • Adipose differentiation is a multi-stage process, progressing from adipoblasts to preadipocytes and finally to mature adipocytes.
  • Terminal differentiation of preadipocytes into adipocytes is regulated by specific adipogenic factors, including circulating hormones and locally produced signaling molecules.

Framework:

  • Hormonal regulation: Growth hormone, glucocorticoids, insulin, and triiodothyronine are key circulating hormones.
  • Local mediators: Prostacyclin and insulin-like growth factor-I (IGF-I) play crucial roles in adipose differentiation.
  • Fatty acids act as signaling molecules, functioning as transcriptional regulators for lipid-related genes.

Implementation:

  • The study focuses on the molecular mechanisms governing the transition from preadipocytes to adipocytes.

Related Experiment Videos

  • Investigates the role of various hormones and fatty acids in regulating gene expression during adipogenesis.
  • Examines the secretory function of differentiated adipocytes and their products.

    • Implications:

    • Understanding adipogenesis is crucial for addressing metabolic disorders associated with adipose tissue.
    • Differentiated adipocytes are active endocrine cells, releasing numerous bioactive compounds.
    • Excess adipose tissue mass may contribute to diverse physiopathological conditions due to altered adipocyte function.