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Related Experiment Videos

Long-term potentiation and synaptic protein phosphorylation

P Pasinelli1, G M Ramakers, I J Urban

  • 1Department of Medical Pharmacology, Rudolf Magnus Institute for Neuroscience, Utrecht University, The Netherlands.

Behavioural Brain Research
|January 23, 1995
PubMed
Summary

Protein kinase C (PKC) activity in synaptic plasticity, like long-term potentiation (LTP), is explored. This review examines PKC

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cellular Signaling

Background:

  • Long-term potentiation (LTP) models activity-dependent synaptic plasticity and memory formation.
  • Pre- and postsynaptic kinases, particularly protein kinase C (PKC), are implicated in LTP molecular mechanisms.
  • Investigating PKC substrate phosphorylation in hippocampal slices offers insight into LTP.

Purpose of the Study:

  • To review the role of protein kinase C (PKC) activity in the early phase of long-term potentiation (LTP).
  • To explore the involvement of PKC substrates, B-50 and neurogranin, in synaptic plasticity.
  • To understand the pre- and postsynaptic roles of PKC in hippocampal LTP.

Main Methods:

  • Review of existing literature on protein kinase C (PKC) involvement in long-term potentiation (LTP).

Related Experiment Videos

  • Focus on in situ phosphorylation studies of PKC substrates in hippocampal slices.
  • Analysis of the roles of B-50 and neurogranin as potential PKC targets.

    • Main Results:

    • Evidence suggests protein kinase C (PKC) plays a role in the early phase of long-term potentiation (LTP).
    • B-50 (GAP43) is identified as a presynaptic substrate implicated in synaptic plasticity and neurotransmitter release.
    • Neurogranin (RC3) is a postsynaptic substrate whose function in LTP requires further determination.

    Conclusions:

    • Protein kinase C (PKC) activity is crucial in both pre- and postsynaptic compartments during early long-term potentiation (LTP).
    • The substrates B-50 and neurogranin are key targets for understanding PKC's role in synaptic plasticity and memory.
    • Further research is needed to fully elucidate the function of neurogranin in the context of LTP.