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Updated: Aug 7, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
[Simultaneous occurrence of medullary and papillary carcinoma in the same thyroid lobe]
1Lehrstuhl für pathologische Anatomie und Zytopathologie, Medizinische Fakultät, Sofia, Bulgarien.
Abstract:
A clinical case of combination between papillary and medullary carcinomas situated in one lobe of thyroid gland is represented. The patient was a 66 year-old female with clinical data for goiter and thyroid scanning revealing a functioning (hot) nodule. Immunohistochemical and ultrastructural evaluation, alongside with routine histological staining were applied for identification of both tumors. Papillary carcinoma cells proved to be pancytokeratin positive and negative for carcinoembryonic antigen and calcitonin. Medullary carcinoma cells showed expression of carcinoembryonic antigen and calcitonin and histochemical methods demonstrated stromal deposits of amyloid. The opportunities for concomitant malignant transformation of thyroid follicular and parafollicular (C) cells are discussed.
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