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Immobilized human serum albumin: liquid chromatography/mass spectrometry as a method of determining drug-protein
P R Tiller1, I M Mutton, S J Lane
1Structural Chemistry Department, Glaxo Research and Development Ltd., Stevenage, Hertfordshire, UK.
Rapid Communications in Mass Spectrometry : RCM
|January 1, 1995
Abstract:
A liquid chromatography/mass spectrometry methodology is described that enables the simultaneous estimation of the individual protein-binding affinities of a mixture of compounds. This approach has proved to be robust and enables a series of molecules to be ranked according to their protein-binding affinities within 20 minutes.