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Urinary calcium excretion in Swedish children
1Department of Paediatrics, Orebro Medical Centre Hospital, Sweden.
Acta Paediatrica (Oslo, Norway : 1992)
|February 1, 1995
Summary
This study established reference ranges for urinary calcium excretion in healthy Swedish children. Results show higher normal urinary calcium/creatinine ratios in younger children, with no link to milk intake.
Area of Science:
- Pediatric Nephrology
- Clinical Chemistry
Background:
- Establishing reference ranges for urinary calcium excretion is crucial for diagnosing hypercalciuria in children.
- Previous studies may not accurately reflect normal urinary calcium levels in pediatric populations.
Purpose of the Study:
- To determine normal urinary calcium/creatinine ratio (UCa/Cr) in a healthy Swedish pediatric population.
- To investigate the correlation between UCa/Cr and age, and cow's milk intake.
Main Methods:
- Measured urinary calcium and creatinine in 153 healthy Swedish children (aged 2-18 years) after an ordinary meal.
- Calculated UCa/Cr and analyzed data for distribution, age correlation, and milk intake correlation.
Main Results:
- The mean UCa/Cr was 0.44 ± 0.379, with 50th and 97th centiles at 0.33 and 1.5, respectively.
- A weak but significant negative correlation was found between UCa/Cr and age.
- No correlation was observed between UCa/Cr and cow's milk intake. Intra-individual variation was 30-40%.
Conclusions:
- The established upper normal limits for UCa/Cr in Swedish children are higher than previously reported.
- Hypercalciuria diagnosis in children requires age-related reference values and repeated measurements in symptomatic individuals.