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Related Experiment Videos

Infantile spasms associated with theophylline toxicity

M D Shields1, E M Hicks, D F Macgregor

  • 1Royal Belfast Hospital for Sick Children, Northern Ireland.

Acta Paediatrica (Oslo, Norway : 1992)
|February 1, 1995
PubMed
Summary

A 6-month-old infant experienced infantile spasms and abnormal EEG results linked to theophylline treatment for asthma. Symptoms resolved after discontinuing theophylline, suggesting a causal relationship.

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Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology
  • Asthma Management

Background:

  • Asthma is a common chronic respiratory disease in infants.
  • Theophylline is a bronchodilator sometimes used in asthma treatment.
  • Infantile spasms are a severe form of epilepsy in infants.

Observation:

  • A 6-month-old infant with asthma developed spasms and hypsarrhythmia on electroencephalogram (EEG).
  • These symptoms emerged shortly after initiating oral theophylline.
  • Theophylline levels were slightly elevated, just above the normal range.

Findings:

  • Discontinuation of theophylline led to the cessation of spasms.
  • EEG normalization occurred after theophylline withdrawal and initiation of nitrazepam.

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  • The infant exhibited normal neurodevelopment over a 3-year follow-up period.

    • Implications:

    • Theophylline toxicity may precipitate infantile spasms in susceptible infants.
    • Careful monitoring of theophylline levels and potential neurological side effects is crucial.
    • Prompt recognition and management can lead to favorable neurodevelopmental outcomes.