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Chronic recurrent multifocal osteomyelitis with unusual features

A Ravelli¹, G L Marseglia, S Viola

¹Clinica Pediatrica, Università di Pavia, IRCCS S Matteo, Italy.

Acta Paediatrica (Oslo, Norway : 1992)

|February 1, 1995

Summary

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Chronic recurrent multifocal osteomyelitis can present with unusual extraskeletal symptoms, including lung issues and atypical skin lesions. This suggests the condition is more varied than previously understood.

Area of Science:

Pediatric rheumatology
Dermatology
Pulmonology

Background:

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder.
Extraskeletal manifestations in CRMO are uncommon but documented.

Observation:

Two pediatric patients with CRMO presented with rare extraskeletal findings.
Patient 1: Asymptomatic pulmonary consolidation.
Patient 2: Pustulosis localized to the trunk, groin, thighs, and buttocks, sparing palms and soles.

Findings:

CRMO exhibits greater clinical heterogeneity than previously recognized.
Extensive and atypical cutaneous involvement can occur in CRMO.
Pulmonary involvement in CRMO may be asymptomatic.

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Implications:

Clinicians should consider a broader spectrum of extraskeletal manifestations in CRMO diagnosis.
Further research is needed to understand the mechanisms behind diverse CRMO presentations.
This expands the differential diagnosis for pediatric patients with unexplained bone and skin lesions.