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The DXS423E gene in Xp11.21 escapes X chromosome inactivation
C J Brown1, A P Miller, L Carrel
1Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Human Molecular Genetics
|February 1, 1995
Abstract:
The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.