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Calculated conformations of sialyl-Le(x)- and sialyl-Le(a)-lactones
1Lund Institute of Technology, University of Lund, Sweden.
Bioorganic & Medicinal Chemistry
|November 1, 1994
Abstract:
The minimum energy conformations of the four sterically reasonable SLe(x) and SLe(a) lactones were calculated using the molecular mechanics force-field MM2(91). The tetrasaccharide lactone involving the 3- and 2-position of the Gal moiety was found to be more stable than the 3,4-lactone both for SLe(x) and SLe(a).