Comparative studies on bioaccumulation of PCDDs and PCDFs in C57BL/6 and DBA/2 mice treated with a mixture by oral

¹Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.

|May 1, 1995

Abstract:

To determine the cause of the extremely high accumulative potency of OCDD in human tissues, EROD activity and accumulation of 2,3,7,8-chlorine substituted PCDDs and PCDFs in liver of C57BL/6 and DBA/2 mice administered these chemicals orally were measured during a period of 28 days. Consequently, in both C57BL/6 mice with high EROD induction and DBA/2 mice with low EROD induction, there was no high accumulation of OCDD similar to that observed in human tissues. In addition, the C57BL/6 mice accumulated larger amounts of these chemicals in their liver than did the DBA /2 mice.

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Abstract:

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Comparative studies on bioaccumulation of PCDDs and PCDFs in C57BL/6 and DBA/2 mice treated with a mixture by oral