Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The human genome--chromosome 9]

R Brdicka1

  • 1Ustav hematologie a krevní transfuze, Praha.

Casopis Lekaru Ceskych
|May 3, 1995
PubMed
Summary
This summary is machine-generated.

Chromosome 9 contains genes for Friedreich

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oncolytic viruses and cancer treatment.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2023
Same author

[The substance of genetic information--nucleic acids].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2012
Same author

Transcriptome alterations in maternal and fetal cells induced by tobacco smoke.

Placenta·2011
Same author

HVRII of mtDNA in cord blood cells of newborn children and in their saliva 10 years later.

Folia biologica·2011
Same author

[Personalized medicine--genomic phase].

Casopis lekaru ceskych·2010
Same author

Effect of maternal tobacco smoke exposure on the placental transcriptome.

Placenta·2010

Area of Science:

  • Human Genetics and Molecular Biology
  • Oncology
  • Biochemistry

Context:

  • Investigates gene loci on chromosome 9 associated with genetic disorders.
  • Examines the BCR-ABL oncogene fusion on chromosome 22 and its role in cancer.

Purpose:

  • To identify and describe specific gene locations on chromosome 9.
  • To elucidate the molecular mechanism of chronic leukemia formation through gene fusion.

Summary:

  • Chromosome 9 harbors loci for Friedreich's ataxia (FRDA), familial malignant melanoma (MLM), acute hepatic porphyria (ALAD), and XPAC, linked to nucleic acid repair defects.
  • The BCR-ABL oncogene fusion, formed by translocation between chromosomes 22 and 9, results in a hyperactive kinase protein characteristic of chronic leukemia's pathological cells.

Impact:

  • Provides foundational knowledge for understanding genetic predispositions to specific diseases.
  • Highlights the significance of chromosomal abnormalities in oncogenesis, particularly in hematological malignancies.