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Dimethylamine in human urine

A Q Zhang1, S C Mitchell, R L Smith

  • 1Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, Paddington, London, UK.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 16, 1995
PubMed
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This study measured dimethylamine (DMA) excretion in healthy adults, establishing normal urinary levels for the first time in females. Most individuals excreted DMA within a specific range, with higher amounts in males potentially linked to diet.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Analytical Chemistry

Background:

  • Dimethylamine (DMA) is a volatile organic compound found in biological systems.
  • Understanding normal urinary DMA levels is crucial for metabolic and toxicological studies.
  • Previous literature lacked comprehensive data on urinary DMA excretion in healthy populations, especially females.

Purpose of the Study:

  • To quantify the daily urinary excretion of dimethylamine (DMA) in a large cohort of healthy volunteers.
  • To establish reference ranges for urinary DMA levels in males and females.
  • To integrate new findings with existing literature on DMA metabolism and excretion.

Main Methods:

  • Collection of 24-hour urine samples from 203 healthy, unrelated volunteers (102 males).

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  • Volunteers maintained their normal dietary habits during the sampling period.
  • Quantitative measurement of urinary dimethylamine (DMA) levels.

    • Main Results:

    • The average daily urinary DMA output was 17.43 ± 11.80 mg.
    • Mean excretion differed between sexes: 21.21 ± 14.78 mg for males and 13.74 ± 5.65 mg for females.
    • Most of the population excreted between 0.68-35.72 mg/day; four males showed significantly higher excretion (up to 109.2 mg), presumed to be diet-related.

    Conclusions:

    • This study provides the first reported urinary dimethylamine (DMA) excretion data for females.
    • Established reference ranges indicate significant variability, with potential dietary influences on higher outputs.
    • The findings contribute valuable baseline data for future research on DMA in health and disease.