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Methadone dosing and pregnancy: impact on program compliance
1Department of Medicine, Roger Williams Hospital, Brown University, Providence, Rhode Island 02908, USA.
A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45. Earlier program entry was associated with decreased opiate and cocaine use and increased compliance with urinalysis requests. The single dose and split-dose groups differed in urine toxicology compliance rates, 23.8 vs 0.5%, as well as percentages of urines positive for cocaine, 15.3 vs 0.3%, only in Trimester III.
A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45. Earlier program entry was associated with decreased opiate and cocaine use and increased compliance with urinalysis requests. The single dose and split-dose groups differed in urine toxicology compliance rates, 23.8 vs 0.5%, as well as percentages of urines positive for cocaine, 15.3 vs 0.3%, only in Trimester III.