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Related Experiment Videos

Methadone dosing and pregnancy: impact on program compliance

P B DePetrillo1, J M Rice

  • 1Department of Medicine, Roger Williams Hospital, Brown University, Providence, Rhode Island 02908, USA.

The International Journal of the Addictions
|January 1, 1995
PubMed
Summary

Daily methadone dosing in pregnant women may improve urine toxicology compliance and reduce cocaine use, particularly in the third trimester. Earlier program entry also correlated with better outcomes.

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Area of Science:

  • Obstetrics and Gynecology
  • Addiction Medicine
  • Pharmacology

Background:

  • Methadone maintenance therapy is crucial for pregnant women with opioid use disorder.
  • Optimal methadone dosing strategies require further investigation to improve treatment outcomes.
  • Understanding factors influencing compliance with urine toxicology is vital for effective monitoring.

Purpose of the Study:

  • To compare the effects of daily versus twice-daily methadone dosing on opiate/cocaine use.
  • To assess the impact of dosing frequency on compliance with urine toxicology requests.
  • To examine these effects in pregnant women undergoing methadone maintenance therapy.

Main Methods:

  • Retrospective, inception cohort, nonrandomized control study design.

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  • Involved 45 pregnant women receiving methadone maintenance therapy.
  • Analyzed data based on daily versus split-dose (twice daily) methadone administration.

    • Main Results:

    • Earlier program entry was linked to reduced opiate/cocaine use and improved urinalysis compliance.
    • Significant differences in urine toxicology compliance rates were observed between single and split-dose groups (23.8% vs 0.5%).
    • Higher percentages of urines positive for cocaine were found in the single-dose group (15.3% vs 0.3%), specifically in Trimester III.

    Conclusions:

    • Split-dose methadone administration may enhance urine toxicology compliance in pregnant women.
    • Twice-daily methadone dosing appears more effective in reducing cocaine use during the third trimester.
    • Early engagement in methadone programs positively influences maternal and fetal outcomes.