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TLC of p-nitroanilines and their analogues with cyclodextrins in the mobile phase
I R Politzer1, K T Crago, T Hollin
1Department of Chemistry, Xavier University of Louisiana, New Orleans 70125, USA.
Journal of Chromatographic Science
|June 1, 1995
Abstract:
The addition of alpha-, beta-, gamma-, and hydroxypropyl-beta-cyclodextrins to aqueous mobile phases can be used to enhance the migration of p-nitroanilines and their analogues on thin-layer chromatography. Urea, which is used to solubilize the cyclodextrins in aqueous solutions, is also found to increase the migration of these compounds. The equilibrium binding constants for the solute-cyclodextrin complexes formed in the mobile phase are determined. The results obtained using either silica gel or polyamide plates are similar.