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Related Experiment Videos

The induction of ovulation

J Evans, L Townsend

    American Journal of Obstetrics and Gynecology
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study demonstrates a successful ovulation induction treatment plan using various medications. The regimen achieved a 99.5% ovulation rate and a 61.9% pregnancy rate in women with ovulatory dysfunction.

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    Area of Science:

    • Reproductive Endocrinology
    • Infertility Treatment
    • Gynecology

    Background:

    • Secondary amenorrhea affects a significant number of women, with identifiable causes in 45% of cases.
    • Careful patient selection is crucial for managing ovulatory dysfunction effectively.
    • Minimizing risks associated with ovulation stimulants is a key consideration in treatment protocols.

    Purpose of the Study:

    • To outline a comprehensive treatment plan for ovulation induction in women with ovulatory dysfunction.
    • To evaluate the efficacy and safety of a multi-agent treatment strategy.
    • To present success rates for ovulation induction and pregnancy across different conditions.

    Main Methods:

    • A treatment plan involving placebo, cyclical steroid therapy, clomiphene citrate, and human pituitary gonadotropin was implemented.

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  • 220 patients with secondary amenorrhea, 145 with oligomenorrhea, and 17 with anovulation were included.
  • Patients were carefully selected based on suitability for ovulation induction.

    • Main Results:

    • Ovulation was successfully induced in 351 out of 352 patients (99.5%).
    • Pregnancy was achieved in 218 out of 352 patients (61.9%).
    • The study details success rates for specific agents across various ovulatory disorders.

    Conclusions:

    • The outlined treatment plan is highly effective for inducing ovulation and achieving pregnancy in women with ovulatory dysfunction.
    • The multi-agent approach, including clomiphene citrate and human pituitary gonadotropin, offers a high success rate with minimized risks.
    • This study provides valuable data on ovulation induction success rates for diverse infertility indications.