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CD30 and type 2 T helper (Th2) responses

S Romagnani1, G Del Prete, E Maggi

  • 1Istituto di Clinica Medica 3, University of Florence, Italy.

Journal of Leukocyte Biology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

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Soluble CD30 (sCD30) and CD30+ T cells indicate T helper 2 (Th2) immune responses. Elevated sCD30 levels and CD30+ T cells are linked to allergic conditions and certain immune disorders.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD30 is a tumor necrosis factor receptor superfamily member, initially identified on Hodgkin's lymphoma cells.
  • CD30 expression is associated with T helper 2 (Th2)-type cytokine-producing T cells.
  • Soluble CD30 (sCD30) is released by activated T cells.

Purpose of the Study:

  • To investigate the association of CD30+ T cells and sCD30 levels with Th2-mediated immune responses.
  • To explore the diagnostic potential of CD30 and sCD30 in various immune conditions.

Main Methods:

  • Analysis of CD30 expression on T cells.
  • Measurement of soluble CD30 (sCD30) serum levels.
  • Correlation of findings with clinical conditions such as allergies, Omenn's syndrome, and viral infections.

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Main Results:

  • CD30 is preferentially expressed on Th2-like T cell clones.
  • Elevated numbers of CD30+ T cells and high sCD30 serum levels are observed in allergic subjects and patients with Omenn's syndrome.
  • Increased sCD30 levels are also noted in systemic lupus erythematosus and after measles or HIV infection.

Conclusions:

  • Detection of CD30+ T cells and elevated sCD30 levels can serve as biomarkers for prevalent Th2 cell activation.
  • These markers may indicate immune alterations in conditions like atopy, immunodeficiency, and autoimmune diseases.