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Related Experiment Videos

Lessons from a case of kleeblattschädel. Case report

D N Thompson1, R D Hayward, W J Harkness

  • 1Craniofacial Centre, Hospital for Sick Children, London, England.

Journal of Neurosurgery
|June 1, 1995
PubMed
Summary

Cloverleaf skull syndrome presents complex anatomical challenges. Surgical complications involving emissary veins can lead to fatal intracranial pressure increases due to venous anomalies.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Cloverleaf skull syndrome is a rare craniosynostosis characterized by a distinctive trilobar skull shape.
  • It often involves complex anatomical abnormalities at the skull base and craniocervical junction, including hindbrain herniation and atlantoaxial instability.

Observation:

  • A case study detailing clinical, radiological, and postmortem findings in cloverleaf skull syndrome.
  • Surgery for vault remodeling led to unavoidable division of occipital emissary veins, causing acute, fatal intracranial hypertension.

Findings:

  • Postmortem and MRI revealed anomalous intracranial venous drainage patterns.
  • These anomalies appeared compensatory to venous obstruction from intraosseous venous sinuses and jugular foramina stenosis.

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Implications:

  • Highlights the critical role of venous hypertension in the pathophysiology of cloverleaf skull syndrome.
  • Underscores the need for careful pre-operative evaluation of venous drainage and potential surgical risks.
  • Suggests revised management strategies for this complex and often fatal disorder.