Related Experiment Video

Updated: Aug 10, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

Safety of ototopical antibiotics

D B Welling1, L A Forrest, F Goll

  • 1Department of Otolaryngology, Ohio State University, Columbus, USA.

The Laryngoscope
|May 1, 1995
PubMed

Insights

A single dose of Cortisporin Otic Suspension after tympanostomy tube insertion showed no increased risk of hearing loss or otorrhea in children. This antibiotic is safe for middle ear infections following tube placement.

Area of Science:

  • Otolaryngology
  • Pediatric Otology
  • Infectious Disease

Background:

  • Tympanostomy tube insertion is a common pediatric procedure.
  • Ototopical antibiotics are frequently used post-procedure.
  • Evidence on the safety and efficacy of single-dose antibiotic use is limited.

Purpose of the Study:

  • To evaluate the safety and efficacy of a single dose of ototopical antibiotics.
  • To assess the impact on hearing and otorrhea after tympanostomy tube insertion.

Main Methods:

  • Prospective randomized study.
  • Fifty children received a single dose of Cortisporin Otic Suspension (COS) in one middle ear.
  • Preoperative and postoperative audiograms and otorrhea assessment were performed.

Main Results:

  • No statistical difference in hearing loss between treated and untreated ears.
  • No significant difference in postoperative otorrhea.
  • One patient experienced bilateral sensorineural hearing loss, unrelated to treatment.

Conclusions:

  • A single dose of COS is safe and effective.
  • Does not increase the risk of hearing loss or otorrhea.
  • Supports the use of single-dose ototopical antibiotics post-tympanostomy tube insertion.

More Related Videos

Intracameral Injection in Rats with Low Risk of Adverse Effects06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Related Concept Videos

Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...